Senin, 23 September 2013

MIRACLE FOR CANCER: HDI PROPOELIX PLUS

WHAT IS HDI PROPOELIX PLUS?
HDI PROPOELIX PLUS is a unique blend of extracts from 4 powerful ingredients:
·         Propoelix
·         Lingzhi,
·         Maitake, and
·         Shiitake.
It is formulated for their synergistic effect as an effective Immunomodulator, where the effectiveness of each ingredient is supported by either Clinical studies or Scientific studies.
This is the first product in the world combining Propoelix and these 3 mushrooms. All 4 ingredients are backed up the extensive evident based research reports for each ingredient. It not only improves our immune systems, but also suppresses the growth of tumor and cancer cells.

Synergic effects of the 4 ingredients make the product more effective as compared to a single ingredient product.

WHAT ARE THE BENEFITS OF HDI PROPOELIX PLUS?
1. Regulates the immune system
Our immune system is made up of a network of cells, tissues, and organs that work together to protect our body against germs, microorganisms, bacteria and a variety of viruses.  In most cases, our immune system does a great job of keeping us healthy by preventing infections. However genetics, stress, bad habits, life style, work pressure, environmental factors such as pollution all contribute to a weakening of our immune system.
The common cold, flu and dengue fever are diseases that are clinically incurable by man-made drugs.  Only our body's immune system with its multi-layer line of biological defense that produces antibodies can prevent and or abate such diseases.   

Propoelix
Propoelix is made from pure high-grade bee propolis extract.   Bee propolis is a sticky material produced by bees to protect their colony from diseases and bacteria, it contains anti-bacterial properties and extra ordinary high antioxidants.  It also has vitamins, minerals, and the 16 essential amino acids required for cell regeneration1. It is rich in beneficial polyphenol that helps increase a person's immunity by strengthening the immune system2.  Propolis has been used for healing as early as 300 B.C. for its antimicrobial, antifungal, antiviral, and anti-inflammatory properties3.  Its high amounts of anti-oxidants, anti-carcinogenic and bioflavanoids makes it a powerful immunomodulator helping to regulate our immune system4.   It also contains high amounts of Caffeic Acid Phenethyl Ester (CAPE), a natural phenolic chemical compound effective in arresting the progression of cancer.  
Propoelix also act as an immuno stimulant which activates the immune system to reject and destroy tumors5, improve cytotoxic(or the quality of being toxic),respond against an antigen6, and restore the immune system weakened by infection or chemotherapy.

It can also act as an immuno suppresor to dampen abnormal immune response in auto-immune diseases such as Lupus and Diabetes Type 1.


Propoelix had been proven in Clinical Studies to help in Dengue Fever as an effective support therapy because of its anti-viral and anti-inflammation properties.(Rochsismandoko, et al, "Clinical Trial of Propoelix (extract of Propoelix) on Dengue Hemorrhagic Fever Patients", February 2013)
Patients using Propoelix experienced significant increase in platelet count [Figure2], rapid decrease in body temperature [Figure3], and shorter length of hospital stay. Furthermore, patients experienced no unwanted side effects or clinical deterioration (Dengue Hemorrhagic Fever or Shock syndrome) [Figure 4]7.



Shiitake (Lentinulaedodes) Mushroom Extract
Shiitake is respected for its high nutritious value. Since the Ming Dynasty, Shiitake is known as "The Emperor's Food"8.   Wu-Rui: "Shiitake accelerates vital energy, wards of hunger, cures cold and defeats body fluid energy". In today's modern science, shiitake's active component, polysaccharides has been proven for its immunostimulating activity9 in many researches. Example of one is by Korean scientists at Kangwon National University, Institute of Bioscience and Biotechnology in 2009. Polysaccharides inside shiitake mushroom has also been identified as immunopotentiators10.

Maitake(Grifolafrondosa) Mushroom Extract
Maitake mushrooms is indigenous to Northern Japan and this rare and tasty mushroom has been praised by traditional Japanese herbalists. Maitake or better known as "dancing mushroom" is highly valued due to its uniqueness and health benefits11.
Maitake Extract with bioactive D-Fraction (protein-bound polysaccharides compound) has been used as an immunotheraphy in murine colon cancer with good result and as an adjuvant therapy on bone marrow-derived dendric cells12.

Lingzhi(GanodermaLucidum) Mushroom Extract
Lingzhi is well known for wide variety of biological activities such as immunomodulatory, anti-tumors, cardiovascular, respiratory, anti-hepatotoxic and antinociceptive effect (active against pain). The major compounds with significant pharmacological activities are ganoderic acid, triterpenes, and polysaccharides13. During the last 3 decades more than 150 triterpenes14,15 and more than 50 carcinostatic polysaccharides have been isolated from this mushroom.Lingzhi 8 as an immunomodulatory protein had been isolated to contain 110 amino-acid16.

2. Function as a Chemopreventive
Propoelix's CAPE properties have preferential cytotoxicity on tumour cells17 and have been found to induce apoptosis (or programmed cell death) to cancer cells in the pancreas18 and colon19. It also inhibited the growth of C6 glioma cells, both in vitro and in vivo20.  Regular intake of CAPE may be beneficial for patients whose tumors express persistently high levels of activated NF-kB, such as non-small cell lung carcinoma, thyroid, colon, breast, stomach, squamous head and neck carcinomas21.

Propolis also contains Artepillin C which is highly cytotoxic to a variety of malignant human solid tumor cell lines22, and polyprenylated benzophenones which demonstrates cytotoxic actvity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251) cell lines23.Propoelix, with its CAPE and Artepillin C content, shows greater efficacy in chemoprevention.

Shiitake's evident based researches are extensive. One was conducted against sarcoma 180, mammary adenocarcinoma 755, leukemia L-121010. A recent research on mice in 2012 was conducted in India. It proved that polysaccharides shows strong tumor regression. And sarcoma tumors (cancer on muscle & bone tissue)disappeared after 5 weeks.  Its Beta Glucan component is especially remarkable  for anti cancer activities8.

Maitake has been proven to induced apoptosis in breast cancer cells24. In 2002, a research provided evidence of significant symptom improvement in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, 62.5 percent of lung cancer patients. It was also reported that there was a 10 - 20 percent improvement for leukemia, stomach cancer and brain cancer patients25.

Lingzhi's chemopreventive function has been clinically tested at the Sloan-Kettering Cancer Centre in USA and considered as 1) chemoprophylaxis (chemotherapic agent for disease prevention) of cancer in individuals at high risk for developing cancer 2) as adjuvant therapy in the prevention of metastasis or recurrence of cancer 3) palliation of cancer-related cachexia and pain 4) adjunctive use with concurrent chemotheraphy to reduce side effect by maintaining leukocyte counts. Lingzhi is also effective in suppressing the tumor cells' growth26.

3.Prevents DNA Damage
Propoelix decreases oxidative stress27 which prevents DNA damage28. The prenylated flavanones (propolins) in propoelix also showed strong scavenging effects against most types of free radicals29.

Cell culture studies show that Propoelix’s polyphenol and flavonoid content are not limited to neutralizing free radicals, but superoxide radicals as well. With an ORAC value of 21.921(compared to 24 for orange), Propoelix is effective in preventing DNA damage.

WHY IS HDI PROPOELIX PLUS THE BEST?
1.       SUPER BLEND
Unlike other propolis products which are usually from a single region, the source of raw propolis for Propoelix is a SuperBlend of propolis from different geographical regions. Each source is tested to ensure it contains superior chemical composition before they are combined for extraction. This unique and complicated process is carried out just to provide you with an extract with consistently effective beneficial properties.  Among the benefits evidenced in laboratories are high antioxidant30, anti-inflammatory31, anti-viral32,anti-cancer33, anti-fungal, anti-bacterial34, anti-allergic, anti-microbial, anti-diabetic35, anti-tumorial36, carbohydrate metabolism promoter, free radical scavenger, and immune system modulator37.

Lingzhi, Maitake, Shiitake extracts  used in HDI PROPOELIX PLUS are carefully selected from high quality sources with consistent polysaccharide values to ensure their quality and effectiveness. The 3 mushrooms' equally wide spectrum of beneficial properties include: anti-bacterial, anti-cancer, immunodulatory, hepatotoxic, cytotoxic, anti-tumorial.

2.       UNIQUE and SUPERIOR EXTRACTION PROCESS
Propoelixutilizes a proprietary Continuous Multi-stage Countercurrent Extraction(CMCETM) process which purifies and remove s99.95% of impurities (such as heavy metals and pesticides) without chemical change—preserving the original amount of micro-nutrients from raw propolis which are usually diluted in traditional steam distillation or solid-liquid extraction38processes.

Also, CMCETM is eco-friendly as it does not require high energy consumption (unlike lyophilization38).
Shiitake, Maitake and Lingzhi have all been extracted to maintain the efficacy of beneficial compounds in the final extraction result.

3.       HIGH POTENCY and BIOAVAILABILITY
Compared to ordinary propolis, Propoelix as one of the main ingredient in HDI PROPOELIX PLUS has higher potency. More importantly, CMCETM maintains a constant concentration of the liquid phase39 of Propoelix— enabling its unique water soluble properties to retain(a) all bioflavonoid, acids, and beneficial compounds intact, and (b)the administered dose unchanged as it reaches the body’s systemic circulation

4.       SYNERGY WITH PRESCRIPTION DRUGS
Research strongly suggests the adjuvant (assisting in the prevention, amelioration, or cure of disease) capacity of propolis is in synergy with vaccines40and antimicrobial drugs41.Combined with vaccines, propolis was able to increase cellular immune response against Suid herpes virus type 1(SuHV-1). As an adjuvant therapy for patients with mild to moderate asthma, propolis showed a marked reduction in the incidence and severity of nocturnal attacks and an improvement of ventilator functions42. Lingzhi has shown that it also functions with synergistic effect by not only reducing the side effects of chemotherapy but also allow the patient’s body to accept a more optimal dose of chemotherapy or radio therapeutics.

5.       SAFE
Propoelixis non-toxic43, does not have side effects, and does not creating resistance in microbial diseases44. Shiitake, maitake and lingzhi extracts used in the product are also thoroughly tested as non-toxic.

WHO SHOULD CONSUMEHDI PROPOELIX PLUS?
Everybody who wants a strong and balanced immune system to prevent the onset of degenerative diseases.
Those with busy lifestyles, lacks sleep and rest, exposed to pollution and experiences high stress. By consuming HDI PROPOELIX PLUS daily, your body is better equipped to fight free radicals and thus help prevent the growth of tumours.
Cancer victims undergoing or completed chemotherapy.
Those diagnosed with immunodeficiency and autoimmune diseases.  To help recover their immune system faster.

DIRECTION FOR USE:
Maintenance: Take one or two capsules, daily.
Cancer Immunotherapy: Take 3 x 4 capsules, daily.
Best to be consumed  before meals.

CONTENT PER BOX:
60 capsules @ 5 blister pack.
Each blister contains 12 capsules.
Each capsule contains:
200mg Propoelix
150mg Lingzi extract
100mg Maitake extract
100mg Shiitake extract

  


HEALTH BREAKTHROUGH
Email: superb.breakthrough@gmail.com
Pin BB: 23605343
Whatapp:+6281232696143
References
1.        Abd El-Hady, F. K., 1994. Gas Chromatography- mass spectrometry (GC/MS) study of the Egyptian propoli-2- Flavonoid constituents. Egypt. I Appl. Sc. 9(8): 91-109
2.        Sforcin, JM., Bankova V., 2011. Propolis: is there a potential for the development of new drugs? T Ethnopharmacol 133 (2): 253–60.
3.        Orsi, R. O., Sforcin J. M., Rall V. L. M., Funari S. R. C., Barbosa L., Fernandes JR A., 2005. Susceptibility profile of Salmonella against the antibacterial activity of propolis produced in two regions of Brazil. Journal of Venomous Animals and Toxins including Tropical Diseases 11 (2): 109–16
4.        Brätter, C., Tregel M., Liebenthal C., Volk H. D., 1999. Prophylactic effectiveness of propolis for immunostimulation: a clinical pilot study. Forsch Komplementarmed. 6 (5): 256–60
5.        Pobojewski S, 2003. Harnessing the Power of the Human Immune System. Medicine at Michigan. University of Michigan.
6.        Overes IM., Fredrix H., Kester MG., Falkenburg JH., Van der Voort R., De Witte TM., Dolstra H., 2009. Efficient activation of LRH-1-specific CD8+ T-cell responses from transplanted leukemia patients by stimulation with P2X5 mRNA-electroporated dendritic cells. J. Immunother. 32 (6): 539–51. 
7.        Rochsismandoko, Eppy, Diana P., Syafiq A., Utami S., Aznan L., Bagus SB., 2013. Clinical Trial of Propoelix on Dengue Hemorrhagic Fever Patients. Medika 2013, the Indonesian Medical Journal, No. 2.
8.        Jasrotia N., Sharma I., Badhani  S., Prashar B.,2012. Incredible Shiitake Mushroom. Manav Bharati University. Solan
9.        Lee., Hwan H., Lee JS., Cho JY., Kim YE., Hong EK., 2008. Molecular  Mechanism of macrophage Activation by  Exopolysaccharides from liquid  culture of Lentinus edodes. Kwangwon National University. Korea
10.     Daba A.S., Ezeronye O.U., 2003. Anti-cancer effect of polysaccharides isolated from higher basidiomycetes mushrooms. University of cape Town. South Africa
11.     Nanba H, Ph.D.,1997. Maitake D-Fraction: Healing And Preventive Potential For Cancer. Kobe Pharmaceutical University.
12.     Masuda Y., Ito K., Konishi M., Nanba H., 2010. A Polysaccharide Extracted From Grifola Frondosa Enhances The Anti-Tumor Activity Of Bone Marrow-Derived Dendritic Cell-Based Immunotherapy Agianst Murine Colon Cancer. Kobe Pharmaceutical University.
13.     Quereshi S., Pandey AK., Sandhu SS.,2010. Evaluation of antibacterial activity of different Ganoderma lucisium extracts. R.D University. Jabalpur.
14.     Kim HW., Kim BK. 2002. Recent advances on the biological active triterpenoids of Ganoderma lucidium.Beijing Medical University Press. Beijing : 10-19
15.     Fang QH., Zhong JJ., Submerged fermentation of higher fungus Ganoderma lucidium for production of valuable bioactive metabolites-ganoderic acid and polysaccharides. Biochemical Engineering Journal; 10: 61-65
16.     Wu TC., Lin YT., Hsu HY., Sheu F., Ho CM., Edmund I., Chen T., 2011. Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cell proliferation via the ribosomal protein S7-MDM2-p53 pathway. National Yang-Ming University. Taipei.
17.     Grundberger, D., Banerjee, R., Eisinger, K., Oltz, E.M., Efros, L., Caldwell, M., Estevez, V., Nakanishi, K., 1998. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44: 230-232. 
18.     Chen, M-J., Chang, W-H., Lin, C-C., Liu, C-Y., Wang, T-E., Chu, C-H., Shih, S-C., Chen, Y-J., 2008. Cells involving caspase and mitochondrial dysfunction. Pancreatology 8 (6): 566-576.
19.     Xiang, D., Wang, D., He, Y., Xie, J., Zhong, Z., Li, Z., Xie, J., 2006. Caffeic acid phenethyl ester induces growth arrest and apotosis of color cancer cells via the β catenin/T cell factor signaling. Anti-Cancer.
20.     Kuo, H-C., Kuo, W-H., Lee, Y-J., Lin, W-L., Chou, F-P., Tseng, T-H., 2006. Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Cancer Letters 234 (2): 199-208.
21.     Bankova, V., 2009. Chemical diversity of propolis makes it a valuable source of new biologically active compounds. Journal of ApiProduct and ApiMedical Science 1(2): 23-28
22.     Konishi, Y., 2005. Transepithelial transport of artepillin C in intestinal caco-2 cell monolayers, Biochim. Biophys. Acta 1713:138-144.
23.     Cuesta-Rubio, O., Frontana-Uribe, B., Ramirez-Apan, T., Cardenas, J., 2002. Polyisoprenylated benzophenones in Cuban propolis; biological activity of nemorosone. Z Naturforschung 57c (3-2): 372-378.
24.     Soares R., Meireles M., Rocha A., Pirraco A., Obiol D., Alonso E., Joos G., Balogh G., 2011. Maitake (D Fraction) Mushroom Extract Induces Apoptosis In Breast Cancer Cells By BAK-1 Gene Activation. University of Porto Foundation. Portugal.
25.     Kodama  N ., Komuta K., Nanba H., 2002. Can Maitake Md-Fraction Aid Cancer Patients?. Kobe Pharmaceutical University.
26.     Xie YZ.,et al, 2005. Ganoderma lucidum inhibits tumour cell proliferation and induces tumour cell death. Guangdong Academy of Sciences. China.
27.     Serarslan, G., Altug, E., Kontas, T., Atik, E., Avci, G., 2007. Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress. Clinical and Experimental Dermatology 32 (6): 709-715.
28.     Evans MD., Cooke MS., 2004. Factors contributing to the outcome of oxidative damage to nucleic acids. BioEssays 26 (5): 533–42. 
29.     Chen, C-N., Wu, C-L., Lin, J-K., 2003. Cytotoxic prelynflavanones from Taiwan propolis. Journal of Natural Products 66 (4): 503-506.
30.     Hirata A., Murakami Y., Shoji M., Kadoma Y., Fujisawa S., 2005. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res. 25 (5): 3367–74. 
31.     Emim JA., Oliveira AB., Lapa AJ., 1994. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J. Pharm. Pharmacol. 46 (2): 118–22. 
32.     Howitz, Konrad T.; Bitterman, Kevin J.; Cohen, Haim Y.; Lamming, Dudley W.; Lavu, Siva; Wood, Jason G.; Zipkin, Robert E.; Chung, Phuong et al., 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (6954): 191–6. 
33.     Ullmannova V., Popescu NC., 2007. Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. Cancer Detect Prev. 31 (2): 110–8. 
34.     Mounnissamy VM., Kavimani S., Gunasegaran R., 2002. Antibacterial activity of gossypetin isolated from hibiscus sabdariffa. Pharmacy Division, Mother Theressa Institute of Health Sciences, Govt. Pharmacy, Gorimedu, Pondichery.
35.     Calderon-Montaño JM., Burgos-Moron E., Perez-Guerrero C., Lopez-Lazaro M., 2011. A review on the dietary flavonoid kaempferol. Mini Rev Med Chem. 11 (4): 298–344. 
36.     Martins, F., Assis, D., Dos Santos, M., Camps, I., Veloso, M., Juliano, M., Alves, L., Doriguetto, A., 2009. Natural polyprenylated benzophenones inhibiting cysteine and serine proteases. European Journal of Medicinal Chemistry. Vol 44, Issue 3, 1230-1239.
37.     http://ajpgi.physiology.org/cgi/content/abstract/279/6/G1148. Bioavailability of the flavanone naringenin and its glycosides in rats"
38.     Tylkowski, B., Trusheva, B., Bankova, V., Giamberini, M., Peev, G., Nikolova, A., 2010. Extraction of biologically active compounds from propolis and concentration of extract by nanofiltration. Journal of Membrane Science 348: 124-130.
39.     Li, W., Zheng,C., Wang, J., Shao, Y., Gao, Y., Ning, Z., Jiang, Y., 2007. Microwave Multi-Stage Countercurrent Extraction of Dihydromyricetin from Ampelopsis grossedentata. Food Technol. Biotechnol. 45 (4) 374-380.
40.     Sforcin, J.M., Propolis and the immune system: a review. Department of Microbiology and Immunology, Bioscience Institute, UNESP. Brazil.
41.     Kujumgiev, A., Tsvetkova, I., Serkedjieva, Y., Bankova, V., Christov, R., Popov, S., 1999. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology 64, 235-240.
42.     Khayyal, M.T., El-Ghazaly, M.A., El-Khatib, A.S., Hatem, A.M., De Vries, P.J.F., El-Shafei, S., Khattab, M.M., 2003. A clinical pharmacological study of the potential beneficial aspects of a propolis food product as an adjuvant in asthmatic patients. Fundamental & Clinical Pharmacology 17, 93-102.
43.     Burdock, G.A., 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology 36, 246-363.
44.     Masihi KN., July 2001. Fighting infection using immunomodulatory agents. Expert Opin Biol Ther 1 (4): 641–53.







Diposting oleh di 3 komentar:
Langganan: Postingan (Atom)